In this case, these researchers developed ROR1-redirected CAR-Ts harboring synthetic Notch (synNotch) receptors specific for EpCAM or B7-H3 (expressed by ROR1-expressing tumor cells but not ROR1-expressing stromal cells) and reported that these CAR-Ts safely mediated efficient tumoricidal activity without toxicity (182). This evidence concerns the gene ROR1 and neoplasm.