ANTXR1 and neoplasm: Moreover, according to in vivo experiments, these researchers indicated that their TEM8-redirected CAR-Ts mediated tumor growth suppression and prolonged survival in localized patient-derived xenograft (PDX) and lung metastatic TNBC cell line LMD231-established xenograft preclinical models and via eliminating TEM8-expressing TNBC tumor cells and targeting the tumor endothelium to prevent further tumor neovascularization (162).