Additionally, in a mouse model of implant-associated osteomyelitis, CXCL10 and CXCL9 were up-regulated in the infected femurs versus controls at 3- and 14-days post-infection (90), suggesting a possible role of these chemokines (produced also by osteoblasts through TLR4 activation (91, 92)) in the pathological bone turnover occurring during Osteomyelitis. This evidence concerns the gene TLR4 and osteomyelitis.