Myocardial fibrosis gradually appears when exposed to an inflammatory environment, such as increased TNFα, IL-1β, and IL-6 cytokine expression, as well as upregulated monocyte chemoattractant protein 1, IL-8, and biglycan expression, leading to overexpression of α-SMA, osteopontin, and lysy-l oxidase (53). Here, IL6 is linked to Myocardial fibrosis.