REN and renovascular hypertension: We used three different hypertensive mouse models to assess the importance of CD8+ T cells for development of cardiac fibrosis: 1) mice whose systolic blood pressure is elevated by trans-aortic constriction (TAC) inducing left ventricular pressure overload 2) mice with high-renin salt-independent 2K1C renovascular hypertension and 3) mice with salt-sensitive low-renin deoxycorticosterone (DOCA)-salt hypertension.