The results of enrichment analysis showed that the high expression of PVT1 was related to DNA repair (base precision repair, cell cycle, DNA replication, homologous recombination, mismatch repair, nucleoside precision repair, p53 signaling pathway, etc.); Low expression of PVT1 was associated with heart disease and depression (arrhythmogenic right ventricular cardiology pathway, calcium signaling pathway, divided cardiology pathway, hypertrophic cardiology pathway, long term depression, etc.). This evidence concerns the gene TP53 and major depressive disorder.