Pathways such as arrhythmogenic right ventricular cardiomyopathy, calcium signaling pathway, dilated cardiomyopathy, hypertrophic cardiomyopathy, and long-term depression were all enriched in the PVT1 low expression group, suggesting that low PVT1 expression was related to heart disease and depression (Supplementary Figure 12F; Supplementary Table 9). Here, PVT1 is linked to depressive disorder.