ZIKV infection was associated with increased secretion of various chemokines (CCL5, CXCL1, CXCL8, CXCL10, and CXCL2) directly linked to the recruitment of immune cells, including T cells, macrophages, and NK cells that are known to actively contribute to the uterine vascular remodeling and the maintenance of fetal tolerance. This evidence concerns the gene CXCL8 and Zika virus infectious disease.