Taken together, our results demonstrate that ZIKV infection increases the production of key chemokines (CCL2, CCL5, CXCL1, CXCL8, and CXCL10) recognized as a major chemoattractant for various immune cell types to the inflamed or infected sites, but also elicits a robust type II and type III IFN response that can efficiently contribute to controlling early steps of ZIKV infection. Here, CXCL10 is linked to Zika virus infectious disease.