In addition to that of cytokines, the population of CD206+ M2 macrophages (Figure 4C), myeloid derived suppressor cells (MDSCs) (Figure 4D), and CD4+ T cells (Figure 4E) reduced more efficiently after treatment with the combination of 5-aza-dC and TSA, while increasing the population of CD86+ M1 macrophages (Figure 4C) and CD8+ T cells (Figure 4F) among the tumor-infiltrating leukocytes in the 4T1 tumor tissues, as compared to those upon treatment with 5-aza-dC or TSA alone and those in the saline-treated group. This evidence concerns the gene CD4 and neoplasm.