Treatment with 5-aza-dC and TSA synergistically decreased the mRNA levels of M2 cytokines (il-10, il-4, and tgfb) and a marker (arg1) in tumor tissues (Figure 4A and Supplementary Figure 4A), while increasing those of M1 cytokines (il-12p40 and ifng) in tumor tissues (Figure 4B and Supplementary Figure 4B), as compared to either therapy alone and in the saline-treated control. The gene discussed is ARG1; the disease is neoplasm.