The cfDII-integrity was significantly able to differentiate HCC from healthy and CLD with AUROC of 0.67 at a cut-off of 0.05 for ALU elements (Figures 2B,C) and AUROC of 0.74 and 0.72, a cut-off of <0.02 for GAPDH gene (Figures 2E,F). Here, GAPDH is linked to hepatocellular carcinoma.