GPT and obesity due to melanocortin 4 receptor deficiency: Furthermore, when obese adolescents were classified by MS criteria or obesity index, the resulting ALT was determined by the high triglyceridemia of these subjects, and hence, predominated TG-enriched lipoproteins, like VLDL and TG-enriched HDL (increase in the ratio HDL-TG/HDL-C) (Figure 1).