A previous study demonstrated that host transcriptome profiles helped build a host transcriptional classifier (NFAT-5, ZC3H11A, and PRRC2C) for diagnosing lower respiratory tract infections with an AUC of 0.88 (95% CI, 0.75-1.00) (Langelier et al., 2018). Here, ZC3H11A is linked to Recurrent lower respiratory tract infections.