A summary data-based Mendelian randomization (SMR) analysis and a transcriptome-wide association study (TWAS) were performed for the severe COVID-19 dataset, and seven novel genes for severe COVID-19 were identified, including CCR5, CCR5AS, IL10RB, TAC4, RMI1, and TNFSF15 (Rao et al., 2021). The gene discussed is TAC4; the disease is COVID-19.