The surface CD81, CD79b and CD20 showed consistent under-expression in CLL, while the presence of ROR1 was also helpful in discerning CLL over mantle cell lymphoma as described in previous studies,17,18,33 especially when interpreted in conjunction with CD200 expression in the ClearLLab B-cell panel.34,35 In the event of a CD19/CD10 co-expressing mature B-cell lymphoid proliferation, CD43 in the DURAClone RE CLB panel was shown to be a useful cell surface marker to discriminate follicular lymphoma from a high-grade B-cell lymphoma. The gene discussed is SPN; the disease is B-cell chronic lymphocytic leukemia.