For example, although the B-cell panel is useful to differentiate precursor B-cell from more mature B-cell LPD, the panel does not accommodate sufficient markers to discern different types of mature LPDs, including CD23, CD43, CD79b and FMC-7 markers necessary to distinguish B-cell LPD per the WHO classification.24 Likewise, markers, such as CD58, for diagnosis for subsequent follow-up of precursor B-ALL, or CD79a and CD81, would be of value in the B-cell panel to discern neoplasm from haematogones. This evidence concerns the gene CD58 and precursor B-cell acute lymphoblastic leukemia.