APOE and early-onset autosomal dominant Alzheimer disease: However, one BBB model did measure adhesion molecule, VCAM-1, in hiPSC-derived pericyte-like mural cells (iMCs) differentiated from an Alzheimer's disease “APOE4/4 risk” line and an “APOE4/4-risk edited to APOE3/3-non-risk” hiPSC line (204).