In addition, previous studies confirmed that a sustained 45 min of exercise not only improves attention, memory, and visuospatial abilities in patients with heart disease but also increases serum brain-derived neurotrophic factor (BDNF) levels and cerebral blood flow in the middle cerebral artery (36) MPA of 75 min per week had the best effect on cognition (37), which is compatible with the results in the present study showed that 30–119 min/d of MPA and LPA have the most beneficial effects on cognition and daily physical function. The gene discussed is BDNF; the disease is heart disorder.