We revealed that CD8A and CD8B of CD8+ T cells were remarkably associated with SPARCL1 expression in BLCA, BRCA, CESC, COAD, ESCA, HNSC, LUAD, LUSC, OV, MESO, PAAD, PRAD, STAD, SKCM, KIRC, KIRP, THYM, UCEC, and UVM. Here, CD8A is linked to bladder transitional cell carcinoma.