Especially, a strong correlation was observed between SPARCL1 and CCL2 of macrophages in COAD and READ (cor = 0.711 and 0.732, respectively), CD115 of monocyte in COAD, PAAD, PRAD, and THYM (cor = 0.615, 0.72, 0.613, and 0.63, respectively), CD86 of monocyte in PAAD and READ (cor = 0.62 and 0.656, respectively), and CD8A of CD8+ T cells in PAAD (cor = 0.695). The gene discussed is SPARCL1; the disease is colon adenocarcinoma.