We revealed the transcriptional level of SPARCL1 was down-regulated in most tumor types, including in BRCA, BLCA, COAD, HNSC, KIRP, LUAD, LUSC, PRAD, READ, THCA, UCEC, CESC, STAD, OV, SKCM, TGCT, and UCEC, but elevated in KICH, KIRC, LIHC, CHOL, DLBC, LGG, and THYM. This evidence concerns the gene SPARCL1 and neoplasm.