CircGNG7 can block the phosphorylation sites of Ser78 and Ser82 and inhibit the phosphorylation of HSP27 in HNSCC, thus inhibiting the phosphorylation of HSP27 in the malignant signaling cascade, which may therefore reduce the chemotherapeutic resistance of HNSCC (133) (Table 1). Here, HSPB1 is linked to head and neck squamous cell carcinoma.