Further in vivo experiments showed that overexpression of CDR1as can upregulat Cyclin E1 (CCNE1) and PIK3CD, the key targets of miR-7, in Hep2 and AMC-HN-8 cells, increasing tumor proliferation index and facilitating tumor growth (25) (Figure 2 and Table 1). The gene discussed is PIK3CD; the disease is neoplasm.