Multivariate analysis revealed that AFP (ng/ml)<400 (HR=0.140, 95%CI, 0.042-0.463, p=0.001), absence of extrahepatic metastasis (HR=0.250, 95%CI, 0.084-0.743, p=0.013), Child-Pugh A (HR=0.316, 95%CI, 0.154-0.650, p=0.002), tumor number<3 (HR=0.337, 95%CI, 0.147-0.776, p=0.011), ICIs combined with anti-angiogenic inhibitors as first-line therapy (HR=0.303, 95%CI, 0.107-0.861, p=0.025), CR/PR to first-line therapy (HR=0.308, 95%CI, 0.122-0.773, p=0.012) and PFS≥6months at first-line therapy (HR=0.093, 95%CI, 0.034-0.258, p=0.001) were independent prognostic factors of favorable PFS (Table 4). The gene discussed is AFP; the disease is neoplasm.