Mechanistic investigation of IL-37 demonstrates that the role of IL-37 (33) is related to promoting differential polarisation of macrophages via promoting M2 towards M1 macrophage polarisation (23), as well as suppression of the maturation of dendritic cells in atherosclerotic plaque (40), thus effectively reducing the development of atherosclerosis (41), which has been confirmed in an IL-37 transgenic animal model (42). The gene discussed is IL37; the disease is atherosclerosis.