This also correlates with the finding that IL-37 transfected peripheral blood mononuclear cells from hepatocellular carcinoma patients (23) promote M2 polarisation into M1 TAMs, subsequently inhibiting hepatocellular carcinoma cell proliferation in vitro, as well as in an animal model (nude mice) via the IL‐6/signal transducer and activator of transcription 3 (STAT3) signalling pathway. This evidence concerns the gene IL37 and hepatocellular carcinoma.