At the same time, multivariate analysis also confirmed MGMT promoter methylation status, IDH mutation status, expression level of Ki67, tumor location, postoperative KPS and TMZ cycles to be strongly associated with overall survival, and MGMT promoter methylation status, IDH mutation status, postoperative KPS and TMZ cycles were independent prognostic factors for progression-free survival. The gene discussed is MGMT; the disease is neoplasm.