It was reported that Tim-3 activation is mediated by PI3K/AKT/mTOR, which plays a key role in inflammatory response (50), and that SHP2 inhibition increases the ratio of CD8+/Treg cells and sensitize tumors to PD-1 inhibition in pancreatic ductal adenocarcinoma (PDAC) and NSCLC models (39). Here, AKT1 is linked to non-small cell lung carcinoma.