An in-depth study of HCC molecular subtyping has provided clues to this phenomenon, reporting that macrotrabecular-massive HCC, characterized by aggressiveness with both angiopoietin 2 (Ang-2) and vascular endothelial growth factor A (VEGFA) overexpression, with a hallmark feature of angiogenesis, was the most common subtype with a high potential for metastasis (22) (23). The gene discussed is ANGPT2; the disease is hepatocellular carcinoma.