A study in diffuse large B-cell lymphoma (DLBCL) have shown an association between a high mutation rate of IgHV and the amplification of PD-L1/PD-L2 (9p24.1), which could explain our limited detection of the ligands in this study; however, this has not been investigated in CLL (9, 35). This evidence concerns the gene PDCD1LG2 and B-cell chronic lymphocytic leukemia.