PROK2 and aneurysm: Genes with inflammatory and immune functions, including interleukin 8 (IL-8), prostaglandin-endoperoxidase synthase 2 (COX2), selectin E (SELE), and prokineticin 2 (PROK2), were confirmed to be overexpressed in aneurysm rupture lesions (Choke et al., 2009).