HK2 and PFKFB3 are involved in glycolysis which affects the immune response against fungal infection (Perrin-Cocon et al., 2021); specifically, after transplantation, the PFKFB3 gene increase the risk of invasive pulmonary aspergillosis (Gonçalves et al., 2021). The gene discussed is PFKFB3; the disease is fungal infectious disease.