It is proven that R98S impacts not only cellular proliferation and ribosome biogenesis (de Keersmaecker et al., 2013), but also leukemic cell metabolism (Kampen et al., 2019a), resistance to pro-apoptotic stimuli (Kampen et al., 2019b), and cross-talk with known leukemia driver pathways, like JAK-STAT (Girardi et al., 2018). Here, SOAT1 is linked to leukemia.