It is therefore not surprising that the most frequent RPL10 mutation in T-ALL, R98S, alters the translation of specific targets, ultimately impacting leukemic cells metabolism (Kampen et al., 2019b) and resistance to pro-apoptotic stimuli (Kampen et al., 2019a), thus conferring an advantage to mutant cells. The gene discussed is RPL10; the disease is acute lymphoblastic leukemia.