In this study, we established a novel nine-gene (IGSF11, CD8A, ALCAM, CLDN6, JAM2, ITGB7, SDC3, CNTNAP1, MPZ) prognostic diagnostic model based on cell adhesion genes, which may provide a new idea for predicting the prognosis of clinical liver cancer patients. Here, IGSF11 is linked to liver cancer.