To clarify the potential factor involved in HSF1-induced PD-L1 expression in HCC, we performed a bioinformatics analysis on genes positively related with HSF1 and PD-L1 respectively as well as negatively related with HSF1 in LIHC extracted from several public cancer databases and found HSF1-induced PD-L1 expression depended on the existence of APOJ in HCC cells. The gene discussed is CD274; the disease is hepatocellular carcinoma.