CLU and hepatocellular carcinoma: As is well-known, APOJ can serve as a multifunctional molecule involved in inflammation and immunity.48 Our previous study identified also APOJ as an inducer of epithelial-mesenchymal transition (EMT) contributing to HCC metastasis;49 of note, the current finding represents a novel function of APOJ in HCC, meanwhile extends our understanding of its roles in establishing immune TME.