Recently, more evidences show that HSF1 promotes cancer-specific immune response and is being recognized as a better target for neoadjuvant immunotherapy.12,46 Furthermore, as a transcription factor, HSF1 can directly initiate the expression of MHC class I molecules, thereby promoting immune recognition and immunotherapy,15 suggesting the regulation of HSF1 on the expression of immune molecules in cancer. This evidence concerns the gene HSF1 and cancer.