To explore the mechanism of HSF1-induced PD-L1 expression in HCC, we extracted genes positively related with HSF1 and PD-L1 respectively as well as negatively related with HSF1 in LIHC from UALCAN database (http://ualcan.path.uab.edu) and further analyzed through performing a GO/KEGG analysis. This evidence concerns the gene HSF1 and hepatocellular carcinoma.