GINS1 and malignant colon neoplasm: Patients with high Psf1 expression in synovial sarcoma have a poor prognosis, and Psf1, as a downstream target gene of Anlotinib, may be a potential therapeutic target for synovial sarcoma.[29] In addition, researches have indicated that Psf1 expression is also significantly upregulated in melanoma, colon cancer and intrahepatic cholangiocarcinoma.[30,31]