In September 2019, a 65-year-old Chinese man with history of former tobacco use (12 pack-years) was diagnosed with compound small cell carcinoma (containing squamous cell carcinoma component) of left lower lobe of lung [cT2aN3M1a, stage IVA (AJCC 8th edition)] without tumor driver gene alterations, the PD-L1 tumor proportion score (TPS) was unknown. This evidence concerns the gene CD274 and neoplasm.