Analysis of the retrieved datasets found that TP inhibited the overexpressed CASP3, CASP8, CCNE1, CXCR4, GSK3B, HSPA5, Janus kinase 2, NFE2L2, PLAU, PTEN and PTGS2 in DKD, while upregulating ESR1 and TGFB1, which were repressed in DKD, promoting each gene restores its proper expression level, thereby treating DKD. This evidence concerns the gene ESR1 and diabetic kidney disease.