In a study seeking an answer to the theory about the increase in lymph node metastasis rate in ER and PR positivity cases or the low rate of lymph node metastasis in triple-negative tumors, it was revealed that histological grade, mitotic score and nuclear pleomorphism increased as a result of increased hormone receptor positivity.[18] It was shown in a study that patients with negative HER2 and ER status had lower lymph node metastasis rates.[19] In our study, no significant relationship was found between lymph node metastasis in the ER (P = .794) and PR (P = .955) groups. The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.