TNF and non-small cell lung carcinoma: Recombinant mutant human tumor necrosis factor for injection (rmhTNF-NC) is a modified rmhTNF, which the toxicity was reduced by 5 times and 10 times higher than that of the wild type.[27] rmhTNF-NC belongs to a novel class of biologic, is mainly used in combination with chemotherapy for refractory advanced non-small cell lung cancer and non-Hodgkin’s lymphoma and also extensively used in the local treatment of advanced-stage thoracic and abdominal effusion.