IL18 and gout: Wang et al[43] studied the mechanism of total saponins of Dioscorea septemloba on gouty arthritis in rats and found that the expression levels of IL-1, ILIL-18d TNF-TNF-erum in rats were significantly increased, suggesting that IL-1β, IL-18, and TNF-α play an important role in the acute attack of gout, which was stronger than the alcohol extract of Dioscorea septemloba.[44] Tufuling has anti-infection and immunity-regulating effects and can promote the metabolism of high uric acid and reduce the level of blood uric acid.