PPARG and gout: Has the effects of clearing away heat and promoting diuresis, and can be used for treating rheumatism caused by downward flow of damp heat, with the symptoms of red and swollen feet and knees and pain of bones and muscles.[24] Modern pharmacological research showed that, Rong, etc.[25] It is believed that PTGS 2, PPARG, CCL 2, IL-6, and CXCL 8 were the key genes for the treatment of gouty arthritis with Simiao decoction.