Wallbach et al reported a case of MPGN in a 40-year-old woman who was being treated for relapsing-remitting MS using IFN-β-1b.[14] She presented with features of renal dysfunction, which included massive proteinuria with protein excretion of 8.3 g/dL, and hypoalbuminemia (serum albumin of 2.9 g/dL). This evidence concerns the gene ALB and Abnormal renal physiology.