CD79A and Cirrhosis: Glomerular IgA deposition occurs in more than 30% of patients with cirrhosis and chronic liver disease due to the impaired function of the damaged Kupffer cells, decreasing IgA-containing complexes clearance, and predisposing IgA deposition in the kidneys.[10] Glomerular IgA deposits are prevalent in advanced liver illness, especially in young patients, but most adults have no clinical feature of glomerular disease.