Compared with patients without AHF, patients with AHF had higher age, more females, higher on admission, higher proportion of previous hypertension and coronary heart disease, more renal insufficiency, and longer total ischemic time, more culprit vessel of LAD and disease, significantly higher CA125 and NT-proBNP, while proportion of RCA as a criminal culprit vessel was lower. This evidence concerns the gene NPPB and Renal insufficiency.