In vitro experimental studies have found that MAPK/ERK activation of the PI3K/AKT signaling pathway can regulate VEGF family factors and affect the expression of cervical oncogenes, which may contribute to the development of cervical cancer.[30] The BACH1-IT1/miR-140-5p/VEGFA pathway axis, MAPK signaling pathway, and key factors VEGFA and FOS may be potential therapeutic targets in cervical intraepithelial neoplasia. This evidence concerns the gene AKT1 and cervical intraepithelial neoplasia.