FOS and cervical carcinoma: In early cervical precancerous lesions, c-Fos expression is relatively low and overall AP -1 binding activity is low, whereas c-Fos expression is high in aggressive cervical cancer.[28] Activation of the MAPK signaling pathway can act on downstream targets to regulate gene expression and affect cell proliferation, migration, apoptosis,[29] epithelial-mesenchymal transition, and treatment.