AKT1 and atherosclerosis: To further identify the related signaling pathways of JHWD on PCOS-IR, the enrichment analyses of PCOS-IR-related targets were performed to confirm that the chief enriched pathways in the progress of PCOS with IR were related to the pathways in cancer, metabolic, PI3K-Akt signaling, lipid and atherosclerosis, as well as MAPK signaling, indicating their importance in the pathogenesis of PCOS with IR.