TNF and polycystic ovary syndrome: Moreover, the clinical validation of this study explored that JHWD exhibited significant clinical efficacy in improving the clinical syndromes, menstrual cyclicity and ovulatory function, and remarkably reduced the lipid levels (TC, TG, and LDL-C), the glucose and insulin levels (FBG, FINS, and HOMA- IRI), and the inflammatory cytokines (TNF-α, IL-6, and IL-1β) in the blood samples of PCOS with IR patients.