It has been reported that the expression of MAPK1 and MAPK3 genotypes were differed significantly between PCOS patients and controls, and they were related to the levels of body mass index (BMI), HOMA-IR, and C-reactive protein (CRP).[25] STAT3 activation is closely associated with PCOS-IR. This evidence concerns the gene MAPK3 and polycystic ovary syndrome.