AKT1 and polycystic ovary syndrome: On the other end, the experimental results of KEGG pathway analysis demonstrated that the key targets of JHWD and PCOS-IR were predominantly associated with the pathways of cancer, lipid and atherosclerosis, PI3K-Akt signaling, hepatitis, human cytomegalovirus infection, advanced glycation endproducts-receptor for advanced glycation endproducts (AGE-RAGE) signaling in diabetic complications, chemical carcinogenesis-receptor activation, kaposi sarcoma-associated herpesvirus infection, chemical carcinogenesis-receptor activation, and MAPK signaling pathway, among others.