Alvaro et al. reported that FGFR1 cooperated with EGFR to enhance the carcinogenic properties of FGFR1 in models of lung adenocarcinoma, and at the clinical level, high FGFR1 expression predicted stronger resistance to first-generation EGFR-TKIs in lung adenocarcinoma patients [137]. The gene discussed is EGFR; the disease is lung adenocarcinoma.