EGFR and non-small cell lung carcinoma: Since the first EGFR-TKI was approved by the FDA in 2003 for the treatment of advanced NSCLC patients whose diseases progressed after platinum plus paclitaxel chemotherapy, the development of EGFR-TKIs has achieved remarkable success, and there have been three generations of EGFR-TKIs used in clinic (Table 1, Fig. 1).