EGFR and non-small cell lung carcinoma: Osimertinib is the first third-generation EGFR-TKI approved by the FDA and EMA for the treatment of metastatic NSCLC patients with the EGFR T790M mutation [21], which irreversibly binds to the cysteine at position 797 (C797) in the ATP-binding site of the EGFR tyrosine kinase domain in a covalent bond formation manner.