In a study of PDT for human colorectal cancer, large amounts of ROS could induce extensive autophagy via activation of the ROS/JNK signaling pathway, while the anticancer efficiency mediated by verteporfin (VP)-PDT was markedly reduced by the additional use of antioxidants and autophagic inhibitors [41], whereas Mao et al. reported that the combination of carboplatin and 9-hydroxypheophorbide α-PDT could inhibit the epithelial-mesenchymal transformation of human laryngeal cancer cells through ROS-mediated inhibition of the MEK/ERK signaling pathway [42]. The gene discussed is MAPK8; the disease is colorectal cancer.