Finally, we investigated if nCounter IFN signaling score was correlated with previously identified HAM/TSP transcriptomic biomarkers (CASP5, FCGR1A, STAT1 identified in [32]) and CXCL10, proposed by several groups [4, 5, 8, 33] as a sensitive biomarker for HAM/TSP disease status and corticosteroid response. The gene discussed is CASP5; the disease is tropical spastic paraparesis.