KPNB1 and amyotrophic lateral sclerosis: Previous studies have reported cytoplasmic mislocalization of KPNB1 in ALS cases [49–53] and Nup62 was found to colocalize with pTDP-43 aggregates in a Drosophila model of traumatic brain injury and human autopsy brain tissue from patients with chronic traumatic encephalopathy (CTE) and ALS/FTLD [54, 55].