SPOCK1 and Sepsis: Among the most significantly downregulated proteins, particularly at D7 and D10, was CNTNAP4 (contactin associated protein family member 4), a presynaptic protein involved in dopaminergic and GABAergic neurotransmission [33], and SPOCK1 (also known as testican-1), a highly conserved proteoglycan that is typically expressed in the thalamus and cerebellum, which was recently identified as a potential biomarker for sepsis [34] (Fig. 5B, C).