In line with our results in MOLM-14 cells, in pancreatic cancer, eIF4Ai impairs both oxidative phosphorylation and glycolysis through altered synthesis of mitochondrial respiration chain components and glucose transporters, therefore forcing the use of glutaminolysis, whereby glutamine-derived α-KG is used to feed the TCA cycle [31]. This evidence concerns the gene EIF4A1 and pancreatic neoplasm.