For Jed41_GB, exome sequencing showed the presence of TC-rare damaging COSMIC variants detected in glioblastoma-associated genes including TP53 [43, 44, 57], LDL receptor related protein 1B (LRP1B) [44, 58], adhesion G protein-coupled receptor E5 (ADGRE5) [59], atrophin 1 (ATN1) [60], autophagy related 2B (ATG2B) [61, 62], MYC associated zinc finger protein (MAZ) [23, 63], WNK lysine deficient protein kinase 1 (WNK1) [64, 65], UDP glucuronosyltransferase family 1 member A1 (UGT1A1) [66], and UDP glucuronosyltransferase family 1 member A6 (UGT1A6) [67]. The gene discussed is TP53; the disease is glioblastoma.