In contrast, in a system such as Jed41_GB, where cells grow slower, have adapted to dysfunctional genes that are important for nuclear integrity such as P53, leukaemia NUP98 fusion partner 1 (LNP1) and Sad1 and UNC84 domain containing 2 (SUN2) [96, 97], the repression of AGR2 could then directly induce apoptosis by enabling the degradation of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl2) and BCL2 Like 1(Bcl2l1), as previously seen in head and neck squamous cell carcinoma cell lines [98]. Here, TP53 is linked to head and neck squamous cell carcinoma.