To systematically analyzed the critical mediators associated with this immunosuppressive TME, proteomic and phosphoproteomic datasets from 103 lung adenocarcinoma (LUAD) cases [11], including 52 wild type (WT) and 51 EGFR-mutated tumors, and paired normal tissues (NT) were selected (Fig. 1A). The gene discussed is EGFR; the disease is lung adenocarcinoma.