There showed an increase in ALP and bone marker osteoprotegerin, osteopenia, and interleukin-6 in cystic angiomatosis [7], where ALP was 393 U/L with the normal of 20–110 U/L, and VEGF of 287.26 pg/ml with a normal of 0–142 pg/ml, which serves as a growth factor with critical pro-angiogenic activity, promoting the vascular permeability and cell migration. This evidence concerns the gene IL6 and Osteopenia.