ANLN and pachyonychia congenita: In this study, the influence of LINC00460 silencing on the proliferation, migration, invasion, apoptosis, and cell cycle of PC cells, the potential regulatory mechanisms of LINC00460/miR-503-5p/ANLN on PC progression, as well as the effects of exosomal LINC00460 on macrophage polarization and metastasis of PC cells were investigated.