IGFBP3 and Familial prostate cancer: In a 6-month study [58] of prostate cancer patients with aerobic or resistance exercise programs, a significant increase in serum IGFBP-3 levels (12.1%; P ≤ 0.05) was observed in the resistance exercise group, while IGFBP-3 levels were reduced by 23.7% (P ≤ 0.05) in the aerobic exercise group.