The following factors were included in the regression model: DR, DMI, DME, DRIL, outer layer disruption, NPA (SCP, SCP + DCP), VD (superior of SCP, centre and superior of DCP, inferior of choriocapillaris), FAZ (area and perimeter of SCP), and systemic factors such as sex, age, HbA1c, EGFR, TG, TCH, duration of diabetes, and the presence of hypertension and diabetic nephropathy. The gene discussed is EGFR; the disease is diabetes mellitus.