IL1B and brain ischemia: IL-1 is secreted by activated astrocytes, oligodendrocytes and infiltrating macrophages after cerebral ischemia, which can promote the expression of adhesion molecules in endothelial cells, thereby aggravating local inflammatory response [48].The level of IL-1β in brain tissue of MCAO model rats began to increase at 6 h and reached the peak at 24 h, indicating that IL-1β was involved in the inflammatory response after cerebral I/R injury [49].